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. 2022 Jul 21;79(8):438. doi: 10.1007/s00018-022-04479-9

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© The Author(s) 2022

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Fig. 6 — Structural insights into the inhibition of HsCBS by AOAA. A Overall fold and conformation of dimeric HsCBSΔ516-525 complexed with AOAA (cyan). B, C The Fo-Fc omit maps contoured at 1σ showing electron density around K119-PLP internal aldimine in chain A (B) and PLP-AOAA adduct in chain B of HsCBSΔ516-525 (C). D, E Residues of HsCBSΔ516-525 interacting with the K119-PLP internal aldimine (D) and PLP-AOAA adduct (E). F Model of HsCBSΔ516-525 with bound Ser based on crystal structure of tScCBS with Ser (PDB# 6C2Q [18]) showing interacting residues with PLP-Ser intermediate