FIGURE 1.

Conserved myogenic tone and impaired K⁺‐induced dilatations in APP and TGF mice. (a) Myogenic tone was conserved in pial arteries of APP and TGF mice for a range of pressure 40–120 mmHg. n = 4 for WT, APP and TGF. (b) K⁺‐induced dilatations were impaired in adult (7–10 months) APP and TGF mice when compared with WT vessels. n = 5 for WT, APP and TGF. *P < 0.05 for ANOVA followed by a Newman–Keuls post hoc comparison test. (c,d) Impaired dilatations were already present in young (3–4 months) APP and TGF mice. n = 3 for WT and TGF; n  = 11 for APP. Error bars represent SEM. Vertical bars represent equal P‐values