TABLE 1.

Allele and genotype frequencies

	Affected ASD subjects in MSSNG database		Unaffected family members in MSSNG database			Allele frequency in NHLBI exome sequencing project
	N individuals	Allele frequency	N individuals	Allele frequency	Allele frequencies of parents reported by Ming et al. (2010)	European‐American	African‐American	Global allele frequency in 1000 genomes
ALA5	4269	0.42	5006	0.41	0.49	0.06	0.04	0.25
ALA6	2575	0.25	2995	0.25	0.30	0.39	0.31	0.41
ALA7	3360	0.33	4157	0.34	0.22	0.55	0.65	0.35

	Affected ASD subjects in MSSNG database		Unaffected family members in MSSNG database		Genotype frequency in NHLBI exome sequencing project
	N individuals	Genotype frequency	N individuals	Genotype frequency	European‐American	African‐American
ALA6/ALA7	627	0.12	712	0.12	0.05	0.04
ALA6/ALA5	1206	0.24	1325	0.22	0.01	–
ALA7/ALA5	927	0.18	1063	0.17	0.02	0.04
ALA7/ALA7	903	0.18	1191	0.20	0.52	0.63
ALA6/ALA6	371	0.07	479	0.08	0.36	0.29
ALA5/ALA5	1068	0.21	1309	0.22	0.05	0.04