Table 1.

Amide bond formation in segmented continuous flow.

Entry	Starting compound(s)	Coupling reagent(s)/ catalysts	Targeted structural scope	Solvent/ T/p	Reactor	# Examples/ yields [%]	Ref.
1		TMA		THF 125 °C		17 65–96	[66]
2		–		neat 245–280 °C 25–35 bar		2 93–94	[67]
					of γ‐Al2O3, MW
3		LHMDS		THF 25 °C		25 24–100	[68]
4		TEA		CHCl3 25 °C		28 49–99	[69]
5		CuBr2 (cat.)		THF 25 °C		32 45–98	[70]
6				toluene 110 °C		1 17[a]	[71]
7		CS2, DMAP, Al2O3		MeCN 200 °C		9 primary+6 secondary 94–98	[72]
8				DCM–DMF 60 °C		16 76–99[a]	[73]
9		ZrO2		diglyme 160 °C		26 19–99	[74]
10		TiO2/NiFe2O4		p‐xylene 150 °C		1 0.02 mol gTiO2 −1 s−1 production rate	[75]
					with inductive heating
11						7 82–93	[76]
				150 °C

[a] Only conversions reported.