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. 2022 Jan 11;61(8):e202112855. doi: 10.1002/anie.202112855

Scheme 1.

Scheme 1

Synthetic approaches to l‐veratrylglycine. a) Sankyo process, requiring the use of an amidase for enzymatic chiral resolution. b) This work: a one‐pot, two‐step enzymatic process involving an O‐methyltransferase (OMT) and ammonia lyase (AL).