Fig. 1.

Human cadaveric ex vivo exocrine isolation. a Schematic of the human pancreas emphasising the ductal endocrine and exocrine organisation. Pancreatic islet illustrated showing the major cell types. Pancreatic exocrine cells were isolated from cadaveric tissue derived from two non-diabetic and a T1D donor. b Representative immunohistochemical insulin and glucagon staining in the non-diabetic donor and T1D donor. Insulin and glucagon expression are indicated by the brown staining in human islets. Note the complete absence of insulin in type 1 diabetic donor