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. 2022 Jul 21;13(7):634. doi: 10.1038/s41419-022-05091-2

Fig. 6. Specific inhibition of mitophagy attenuates hypoxic pulmonary hypertension (PH).

Fig. 6

A Cell-permeable peptide P (unphosphorylated FUNDC1 Tyr18) and C (phosphorylated FUNDC1 Tyr18). Co-IP showing the FUNDC1/LC3 interaction in pulmonary artery smooth muscle cells (PASMCs) pretreated with peptide P or C (250 nM) 1 h before hypoxia. B Timetable and procedure of hypoxia treatment with peptides. C Confocal images showing mt-Keima signal in mt-Keima mice treated as in (A). n = 4–6 mice per group, scale bar: 25 μm. D Pulmonary arterial wall thickness and E Ki67-positive cells in pulmonary arteries. n = 8–12 mice per group, scale bar: 50 μm. F RVSP and G PAAT. n = 6 mice per group for (F), and n = 6-7 mice per group for G. Data are presented as mean ± SD. p values were determined by one-way ANOVA. Bonferroni post hoc analysis were carried out after ANOVA.