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. 2022 Jul 21;13:4119. doi: 10.1038/s41467-022-31262-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — MRI showed enlargement of the entire enhanced lesion with clearing of contrast enhancement at the injection site (arrows) post-G47Δ administration. All specimens from pre-administration were negative for HSV-1 immunostaining. Second biopsy specimens obtained before the second injection from the same coordinates of the first G47∆ injection 7 days (a) and 6 days (b) post-administration showed decreased number of tumor cells, possibly due to tumor cell destruction associated with viral replication (H&E) and positive HSV-1 immunostaining. An increase in infiltration of CD4⁺ and CD8⁺ T lymphocytes towards remaining tumor cells was observed. Pathology images are representative of four biopsy specimens.