Table 3.

The area under the curve values and accuracy of various multiple biomarkers (at fixed specificity)

Biomarker set	AUC	Specificity (%)	Sensitivity (%)	PPV (%)	NPV (%)
CA125, HE4, CA15.3, CEA, ApoA1, ApoA2	0.965	90.45	93.71	89.93	94.04
CA125, HE4, CYFRA21.1, CA15.3, ApoA1, ApoA2	0.965	90.45	93.01	89.86	93.42
CA125, HE4, ApoA1	0.966	90.45	91.61	89.73	92.21
CA125, HE4, CA15.3, CEA, ApoA1	0.966	90.45	93.01	89.86	93.42
CA125, HE4, CEA, ApoA1, ApoA2	0.966	90.45	93.71	89.93	94.04
CA125, HE4, CYFRA21.1, ApoA1, ApoA2	0.966	90.45	93.01	89.86	93.42
CA125, HE4, CA15.3, TTR, ApoA1	0.967	90.45	91.61	89.73	92.21
CA125, HE4, ApoA1, ApoA2	0.967	90.45	93.71	89.93	94.04
CA125, HE4, CEA, ApoA1	0.967	90.45	91.61	89.73	92.21
CA125, HE4, CA15.3, ApoA1, ApoA2	0.970	90.45	93.71	89.93	94.04

AUC, area under the curve; PPV, positive predictive value; NPV, negative predictive value; CA125, carbohydrate antigen 125; HE4, human epididymis protein 4; CA15.3, cancer antigen 15-3; CEA, carcinoembryonic antigen; ApoA1, apolipoprotein A1; ApoA2, apolipoprotein A2; CYFRA21.1, cytokeratin fragment 21-1; TTR, transthyretin.