FIGURE 1.

Inductive sites of tumor-specific immune responses. Tumor cells express tumor associated antigens (TAAs) sampled by dendritic cells that migrate to tumor draining lymph nodes where adaptive immune responses are triggered. Tumors also feature tertiary lymphoid structures (TLS) where tumor specific T and B cells can be primed. In both cases, activated tumor-specific CD4⁺ and CD8⁺ T cells migrate within the tumor mass and attack transformed cells, ultimately inducing apoptotic cell death. Also plasma cells participate in antitumor immunity by producing tumor specific antibodies. aCD4, activated CD4 T cell; aCD8, activated CD8 T cell; nCD4, naive CD4 T cell; nCD8, naive CD8 T cell; PC, plasmacell; cDC, conventional dendritic cell; FDC, follicular dendritic cell. Created with BioRender.com.