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Overview of the 11 PRSs considered. The inputs are female-specific GWAS summary statistics, male-specific GWAS summary statistics, and sex-agnostic GWAS summary statistics; PRS methods include PRScs, LDpred2, and PRScsx; validation samples are used to tune hyperparameters of PRSs and find the optimal weights of sex-specific PRSs; testing samples are to assess prediction accuracy.
