TABLE 3.
Various formulations of Carbopol 934P-NF containing ketoconazole and silver nanoparticles.
| Ingredient | Formulations | ||||||
|---|---|---|---|---|---|---|---|
| Blank gel | PLGA NP gel | Keto NP gel | Keto PLGA NP gel | Keto-drug gel | AgNP gel | Keto PLGA NP + AgNP gel | |
| Carbopol gel 934P-NF | 2% | 2% | 2% | 2% | 2% | 2% | 2% |
| Blank PLGA NPs | — | 16.5% | --- | — | — | — | — |
| Ketoconazole NPs | — | 2% | — | — | — | — | |
| Ketoconazole PLGA NPs | — | — | — | *16.5% | — | — | *16.5% |
| Ketoconazole pure Drug | — | — | — | — | 2% | — | — |
| Silver NPs | — | — | — | — | — | 1% | 1% |
PLGA NPs (100% PLGA NPs), ketoconazole NPs (100% ketoconazole NPs), ketoconazole PLGA NPs (12.5% ketoconazole + 87.5% PLGA NPs) *(16.5% w/v particles correspond to 2% ketoconazole pure drug based on entrapment efficiency).