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. 2022 Jun 30;25(8):104686. doi: 10.1016/j.isci.2022.104686

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© 2022 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Differential gene expression in excitatory and inhibitory neurons after prenatal e-cigarette exposure

(A and C) Volcano plots showing differentially expressed genes (DE-Gs) in all the excitatory neurons (A) or inhibitory neurons (C) collected from control or maternal e-cigarette exposed P7 rat brains. Blue and red lines indicate log2FoldChange of ±0.2.

(B) Violin plots showing the expression of Camta1in six excitatory neuronal subtypes.

(D) Violin plots showing the expression of Camta1 and Capn13 in three inhibitory neuronal subtypes.

(E) Manhattan plot showing the top Gene Ontology (GO) terms (MF, molecular function; CC, cellular component; BP, biological process), and Kyoto Encyclopedia of Genes and Genomes (KEGG), enriched from the DE-Gs identified in all neurons between control and e-cigarette exposed P7 rat brains.