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. 2022 Jul 8;13:923424. doi: 10.3389/fimmu.2022.923424

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Copyright © 2022 Xie, Zhang, Dai, Yue, Li, Qiu, Lu and Xu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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scRNA-seq analysis of adult BM lin^-IL7Rα⁺ cells reveals the heterogeneity of the IL18Rα⁺ population. (A) Lin^-IL-7Rα⁺ cells sorted from the BM of wild-type mice. UMAP plot shows the distinct clusters within 12,643 sequenced cells. (B) UMAP expression of lymphoid progenitor or ILC-associated genes in clusters in panel (A, C) Expression of candidate genes within BM lin^-IL-7Rα⁺ cell clusters. (D) UMAP plot of cluster 6 from panel (A, E) Heatmap of selected lymphoid progenitor/ILC-associated genes by 5 clusters in panel (D).