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. 2022 Jul 8;12:913487. doi: 10.3389/fonc.2022.913487

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Copyright © 2022 Veltri, Lovisa, Cortese, Pillon, Carraro, Cesaro, Provenzi, Buffardi, Francescato, Biffi, Buldini, Conter, Serafin and Mussolin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differentially expressed proteins between stage IV and stage III T-LBL samples. (A) Hierarchical clustering graph (HCG) of all proteins, and a set of proteins being positively associated with stage IV or stage III T-LBL, with different intensities (height of columns is equal to p-values of single tests). Positive association with stage IV T-LBL (or T-ALL) refers to hyperactivated proteins in stage IV T-LBL (or in T-ALL). (B) Heatmap of the three significantly differentially expressed proteins between stage IV and stage III T-LBL samples (based on non-corrected p-values from single tests). (C) AKT S473/tot phosphorylation levels measured by RPPA analysis were significantly upregulated in stage IV T-LBL samples (n=8) compared to both T-ALL (n=57) and stage III T-LBL (n=14).*p < 0.05; ***p < 0.001.