TABLE 1.

The inflammatory cells involved in ASIC1a.

Inflammatory cells type	Expression and major physiological function	References
Macrophages	Bone marrow derived macrophages express ASIC1, and ASIC1 contribute to increased endocytosis of FITC-dextran and upregulated expression of CD80, CD86, and MHC-II in BMMs stimulated by acidosis	Kong et al. (2013)
Microglia	ASIC1 in microglia is increased upon stimulation with LPS. Blocking of ASIC1a reduced the expression of inflammatory cytokines	Yu et al. (2015)
Dendritic cells	Dendritic cells express ASICs, acidosis upregulated the expression of CD11c, MHC class II, CD80, and CD86 and enhanced the Ag-presenting ability of dendritic cells via ASICs	Tong et al. (2011)
T cells	T cells show ASIC1 expression at the protein level, ASIC1 has no significant role in T cell function in EAE	Friese et al. (2007)
B cells	Asic1 mRNA is detected in B cells	Friese et al. (2007)
Eosinophils
Neutrophils	ASIC1a is detected in these five inflammatory cells, indicating the key roles of ASIC1a in the infiltration and activation of these inflammatory cells	Tang et al. (2021)
Mast cells
Plasma cells
Th cells