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. 2022 Jul 8;10:919438. doi: 10.3389/fcell.2022.919438

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Copyright © 2022 Centrone, D’Agostino, Ranieri, Mola, Faviana, Lippolis, Silvestris, Venneri, Di Mise, Valenti and Tamma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Functional characterization of endogenous V1aR receptors in HCT8 cells. Cells were stimulated with 1 µM dDAVP or with 1 µM dDAVP and 100 nM SR49059, a V1aR antagonist. ATP (100 µM) stimulation was used as a positive control. dDAVP significantly increased cytosolic calcium. Stimulation with dDAVP in the presence of 100 nM SR49059 prevented the effect of dDAVP raising cytosolic calcium. Data are expressed as means ± S.E.M. and analyzed by one-way ANOVA followed by Tukey’s multiple Comparisons test (***p < 0.001 vs. ATP; ^$$$ p < 0.001 vs. dDAVP).