TABLE 1.
Glycerol permeability, cell viability and total area of cell. Values represent the mean ± S.E.M. and analyzed by one-way ANOVA followed by Dunnett’s Multiple Comparison test. *Significantly different versus Untreated (****p < 0.0001, **p < 0.01, *p < 0.05). #Significantly different versus DMSO (#### p < 0.0001, ### p < 0.001, ## p < 0.01).
| Parameters | Untreated | DMSO | dDAVP | dDAVP/TLV | dDAVP/SR49059 | dDAVP/SR49059/DFP001 | DFP00173 | TLV | SR49059 |
|---|---|---|---|---|---|---|---|---|---|
| Glycerol permeability | 100 ± 2.72 | 94.14 ± 4.18 | 62.46 ± 3.27 | 65.49 ± 2.56 | 96.04 ± 4.15 | 42.30 ± 1.57 | 45.72 ± 2.23 | 88.67 ± 5.68 | 101.6 ± 4.94 |
| **** | **** | **** | **** | ||||||
| #### | #### | #### | #### | ||||||
| n = 428 cells | n = 181 cells | n = 87 cells | n = 108 cells | n = 160 cells | n = 138 cells | n = 93 cells | n = 96 cells | n = 71 cells | |
| Cell Viability | 100 ± 6.55 | 106.3 ± 7.00 | 71.14 ± 3.38 | 64.59 ± 6.09 | 102.9 ± 3.70 | 76.42 ± 2.99 | 80.33 ± 1.2 | 98.3 ± 6.36 | 114.4 ± 2.97 |
| *** | **** | ** | * | ||||||
| #### | #### | ### | ## | ||||||
| n = 6 | n = 6 | n = 6 | n = 6 | n = 6 | n = 6 | n = 6 | n = 6 | n = 6 | |
| Total Area of cell | 100 ± 6.51 | 89.54 ± 5.31 | 47.07 ± 3.00 | 46.12 ± 4.13 | 86.16 ± 6.63 | 50.23 ± 1.82 | 69.77 ± 8.07 | 88.38 ± 3.51 | 88.83 ± 11.94 |
| **** | **** | **** | * | ||||||
| #### | #### | ## | |||||||
| n = 6 | n = 6 | n = 6 | n = 6 | n = 6 | n = 3 | n = 3 | n = 3 | n = 3 |