TABLE 2.

Ferroptosis inducers and inhibitors.

Reagents	Target	Function	Effect
Erastin	System XC −	Restrains systemic XC − activity, inactivates the GPX4 enzyme, causes GSH depletion and induces ROS formation	Induces ferroptosis
RSL3	GPX4	Binds and inactivates GPX4 and develops lipid ROS levels	Induces ferroptosis
Glutamate	System XC −	Inhibits cystine uptake and glutathione synthesis at high concentrations	Induces ferroptosis
Artemisinin	Unknown	Produces ROS and causes oxidative stress	Induces ferroptosis
Vitamin E (Alpha-tocopherol)	5-lipoxygenase	Inhibits ferroptosis via LOX suppression and controls cellular redox homeostasis	Inhibits ferroptosis
Deferoxamine	Fe2+	Chelates excess iron, inhibits ROS accumulation and cell death	Inhibits ferroptosis
Ferrostatin-1	ROS	Decrease the accumulation of lipid ROS by collecting radical antioxidants without inhibition of LOX activity	Inhibits ferroptosis
Liproxstain-1	ROS	Decrease the accumulation of lipid ROS by collecting radical antioxidants without inhibition of LOX activity	Inhibits ferroptosis
Zileuton	5-lipoxygenase	Controls cellular redox homeostasis	Inhibits ferroptosis