TABLE 1.
Demographic and clinical variables relative to the studied population of subjects.
| Controls No. 20 | ERA T0 No. 19 | ERA T1 No. 19 | Significance | |
| Sex male n (%) | 1 (5%) | 9 (45%) | – | a |
| Age (years) median (IQR) | 53.5 (40.8–56.0) | 61.0 (46.5–66.5) | – | |
| ACPA median (IQR) | 0 (0–0) | 320.0 (206.5–566.0) | 92.0 (30.7–268.5) | a,b |
| RF median (IQR) | 0 (0–0) | 86.0 (23.5–237.5) | 20.5 (0–59.2) | a,b |
| ESR median (IQR) | 12.0 (8.0–19.2) | 35.0 (21.5–52.5) | 13.5 (6.0–20.0) | a,b |
| CRP median (IQR) | 0.055 (0–0.2) | 1.0 (0.41–1.45) | 0.2 (0.07–0.37) | a,b |
| CDAI | – | 21.5 (17.0–31.7) | 3.5 (2.25–16) | b |
| SDAI | – | 23.5 (18.0–37.5) | 3.5 (2.25–17.875) | b |
| DAS28 | – | 5.5 (4.4–6.3) | 2.3 (1.9–3.8) | b |
| CD4plus% median (IQR) | 40 (31.5–45.2) | 42.0 (38.0–45.8) | 38.7 (34.2–42.6) | |
| Treg% median (IQR) | 1.4 (1.1–1.8) | 1.0 (0.8–1.3) | 1.1 (1.0–1.8) | a,b |
| Th17% median (IQR) | 0.85 (0.77–1.22) | 1.8 (1.3–2.7) | 1.5 (1.0–2.2) | a,b |
| IL9 median (IQR) | 2.8 (0.7–3.2) | 2.6 (1.9–11.9) | 2.6 (1.0–5.4) | |
| TGFb median (IQR) | 2513.4 (1782.7–3790.6) | 1919.7 (1108.6–4185.5) | 1903.4 (566.0–4103.7) | |
| TNF-alpha | – | 3.3 (0–8.3) | 0 (0–1.3) | b |
| IL6 | – | 35.1 (16.1–49.8) | 13.6 (8.5–21.6) | b |
Statistical significance at alpha levels 0.05. a: Controls vs. ERA T0, b: ERA T0 vs. ERA T1.