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. 2022 Jul 17;16:2305–2323. doi: 10.2147/DDDT.S368836

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© 2022 Wang and Wang.

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Mechanism of diosgenin and its analogs in regulating atherosclerosis. Diosgenin and its analogs improve AS by regulating endothelial dysfunction (eg, vascular tension, oxidative stress, leukocyte adhesion, platelet aggregation, and thrombosis), inhibiting proliferation, migration, and calcification of VSMCs, regulating lipid metabolism (eg, ameliorating hyperlipidemia, inhibiting foam cell formation, promoting liver cholesterol excretion, and inhibiting intestinal cholesterol absorption), and inhibiting inflammatory processes.