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. 2022 Jul 8;13:915935. doi: 10.3389/fphar.2022.915935

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Copyright © 2022 An, Zhao, Han, Sun, Liu and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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VIP values (A) and mean change (means with 95% confidence intervals) (B) in differential metabolic measures with VIP >1 and p < 0.05 in pregnant women diagnosed with PROM compared with healthy pregnant women. The red symbols indicate that the fold change of the particular metabolite in the PROM cohort were upregulated (fold change >1); green symbols (fold change <1) represent downregulated metabolites.