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. 2022 Jul 8;13:915935. doi: 10.3389/fphar.2022.915935

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Copyright © 2022 An, Zhao, Han, Sun, Liu and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Functional metabolite groups altered in women with PROM in early pregnancy. (A) The correlation network of the altered metabolites in PROM. The node represents a compound, and each edge represents the strength of correlation between two compounds. Edge weights represent Pearson’s correlation coefficients. The red/green nodes represent upregulated/downregulated metabolites in the PROM cohort. The red/blue edges indicate positive/negative correlations between two metabolites. (B,C) Correlation matrix colored by the Pearson correlation coefficient (r) of each pair of PROM-related compounds across samples. (D–H) The linear model of top five highly correlated (R ² > 0.6) pair of PROM-related metabolites. The 95% confidence interval for the linear regression is represented by the gray area.