Table 3.
MVMR result after adjusting the interactions between FAs.
| Outcome | Exposures | NumberofSNPs | Effect | SE | MVMR P Value |
|---|---|---|---|---|---|
| LS-BMD | Omega-3 fatty acids | 44 | −4.612 | 5.0848 | 0.3643 |
| Omega-6 fatty acids | 47 | 1.6421 | 1.8519 | 0.3752 | |
| Ratio of omega6/omega3 | 28 | −4.0504 | 4.5302 | 0.3712 | |
| FN-BMD | Omega-3 fatty acids | 44 | 2.3857 | 3.5399 | 0.5003 |
| Omega-6 fatty acids | 47 | −0.8907 | 1.2893 | 0.4896 | |
| Ratio of omega6/omega3 | 28 | 2.1271 | 3.1539 | 0.5000 | |
| FA-BMD | Omega-3 fatty acids | 44 | −6.9028 | 6.9061 | 0.3175 |
| Omega-6 fatty acids | 48 | 2.5533 | 2.5146 | 0.3099 | |
| Ratio of omega6/omega3 | 28 | −6.0379 | 6.1529 | 0.3264 | |
| TB-BMD | Omega-3 fatty acids | 49 | 1.1004 | 3.3400 | 0.7418 |
| Omega-6 fatty acids | 57 | −0.4604 | 1.2164 | 0.7050 | |
| Ratio of omega6/omega3 | 31 | 0.9961 | 2.9757 | 0.7378 |
MR, Mendelian randomization; BMD, bone mineral density; FN-BMD, femoral neck BMD; LS-BMD, lumbar spine BMD; FA-BMD, forearm BMD; TB-BMD, total body BMD; SNPs, single nucleotide polymorphisms; IVW, inverse variance weighted; SE, standard error; CI, confidence interval.