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. 2022 Jul 8;13:910868. doi: 10.3389/fendo.2022.910868

Figure 2.

Figure 2

Effects of METTL3 on GSIS from pancreatic β cells. (A, B) Immunoblot of METTL3 protein expression in NIT-1 cells transfected with METTL3 siRNA (si-METTL3) or a nonspecific control siRNA (si-NC), which was set to 1. (C) The GSIS index of NIT-1 cells transfected with si-METTL3 or si-NC. (D, E) Immunoblot of METTL3 protein expression in NIT-1 cells (MG), NIT-1 cells transfected with METTL3 expression adenovirus (MG+Ad-METTL3), and NIT-1 cells transfected with a nonspecific control adenovirus (MG+Ad-NC) that were treated with 1 mM of MG for 24 h. (F) The GSIS index in NIT-1 cells was transfected with Ad-METTL3 or Ad-NC and treated with 1 mM of MG for 24 h. Results are presented as the means ± SD of n = 3–4 independent experiments. * p < 0.05.