Histological assessmentwith H&E staining (original magnification × 200). (A) The pathological analysis of muscle tissue in mice; (B) The pathological analysis of kidney tissue in mice. Black arrows were used to show the tissue injuries of mice after exhausted swimming stress. Differences were analyzed with one-way ANOVA and Duncan's new multiple range test. a–e Different letters mean significant difference (P < 0.05). Data are expressed as mean ± S.E.M. (n = 6). The abbreviation of groups used in the figure were: blank control (Rest), swimming control (Con), Vitamin C (Vc), low-dose curcumin (C50), middle-dose curcumin (C100), and high-dose curcumin (C200).