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. 2022 Jul 14;8(7):e09955. doi: 10.1016/j.heliyon.2022.e09955

Table 2.

Pharmacokinetic parameters of CA with chitosan and without chitosan in rats after gavage administration.

Parameters With chitosan Without chitosan
Cmax (ng/mL) 1279.3 ± 557.9∗ 635.8 ± 128.3
Tmax (min) 120.0∗ 300.0
t1/2,λz (min) 389.9 ± 51.5 333.0 ± 86.4
AUC0-t (μg·min/mL) 724.9 ± 232.5∗ 439.2 ± 123.
AUC0-∞ (μg·min/mL) 787.8 ± 248.5∗ 451.9 ± 136.6
CL/F (mL/min/kg) 27.9 ± 10.4 35.7 ± 23.8
Vd,λz/F (mL/kg) 15612.1 ± 5507.6 16794.1 ± 12638.5
F (%) 174

Notes: Each value represents the mean ± SD (n = 5). Significant differences were accepted at p < 0.05 (∗).