Table 2.

Performance characteristics of the BCID2 compared to conventional culture shown for each target for monomicrobial samples.

Microorganism	TP (n) [BC+/BCID2+]	FP (n) [BC-/BCID2+]	FN (n) [BC+/BCID2-]	TN (n) [BC-/BCID2-]	SE (%)	95% CI (%)	SP (%)	95% CI (%)
Staphylococcus spp.	12a	0	0	48	100	73.5–100	100	92.6–100
S. aureus	7	0	0	53	100	59–100	100	93.3–100
S. epidermidis	3	0	0	57	100	29.2–100	100	93.7–100
S. lugdunensis	0	0	0	60	NA	-	100	94.1–100
Streptococcus spp.	9b	0	0	51	100	66.4–100	100	93–100
S. agalactiae	0	0	0	60	NA	-	100	94.1–100
S. pyogenes	1	0	0	59	100	2.5–100	100	93.9–100
S. pneumoniae	4	0	0	56	100	39.8–100	100	93.6–100
E. faecalis	2	0	0	58	100	15.8–100	100	93.8–100
E. faecium	1	0	0	59	100	2.5–100	100	93.9–100
L. monocytogenes	0	0	0	60	NA	-	100	94.1–100
Gram positives, overall	24	0	0	36	100	85.8–100	100	90.3–100
A. calcoaceticus-baumannii	0	0	0	60	NA	-	100	94.1–100
Bacteroides fragilis	1	0	0	59	100	2.5–100	100	93.9–100
H. influenzae	0	0	0	60	NA	-	100	94.1–100
N. meningitidis	0	0	0	60	NA	-	100	94.1–100
P. aeruginosa	1	0	0	59	100	2.5–100	100	93.9–100
S. maltophilia	0	0	0	60	NA	-	100	94.1–100
Enteric bacteria	26	1c	0	33	100	86.8–100	97.1	84.7–99.9
E. coli	23	0	0	37	100	85.2–100	100	90.5–100
E. cloacae complex	0	0	0	60	NA	-	100	94.1–100
K. aerogenes	0	0	0	60	NA	-	100	94.1–100
K. oxytoca	1	0	0	59	100	2.5–100	100	93.9–100
K. pneumoniae	1	0	0	59	100	2.5–100	100	93.9–100
Proteus spp.	1	0	0	59	100	2.5–100	100	93.9–100
Salmonella spp.	1	0	0	59	100	2.5–100	100	93.9–100
S. marcescens	0	0	0	60	NA	-	100	94.1–100
Gram negatives, overall	28	1	0	31	100	87.7–100	96.9	83.8–99.9
C. albicans	1	0	0	59	100	2.5–100	100	93.9–100
C. auris	0	0	0	60	NA	-	100	94.1–100
C. glabrata	0	0	0	60	NA	-	100	94.1–100
C. krusei	0	0	0	60	NA	-	100	94.1–100
C. parapsilosis	1	0	0	59	100	2.5–100	100	93.9–100
C. tropicalis	0	0	0	60	NA	-	100	94.1–100
C. neoformans/gattii	0	0	0	60	NA	-	100	94.1–100
Yeasts, overall	2	0	0	58	100	15.8–100	100	93.8–100

TP = True Positives; FP = False Positives; FN = False Negatives; TN = True Negatives; BC = Blood Culture; BCID2 = Blood Culture Identification 2 Panel; SE = Sensitivity; SP = Specificity; CI = Confidence Interval.

^aIncluding 2 off-panel species (S. hominis and S. capitis).

^bIncluding 4 off-panel species (S. intermedius, S. constellatus, S. group C and S. group D).

^cThis sample grew B. cereus according to traditional methods confirmed by whole genome sequencing.