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. 2022 Jul 8;13:929089. doi: 10.3389/fimmu.2022.929089

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Copyright © 2022 Li, Liu, Zhang, Xu, Zhang, Wei, Zhang, Zhang, Feng, Li and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Clinical relevance and model comparison. (A) Heatmap of correlations between prognostic signature and clinicopathological features. (B) Histograms showing the distribution of grade, stage, and T between the high- and low-risk groups. (C–F) Kaplan–Meier analyses of the signature stratified by stage and grade. (G) Multivariate ROC curves of different HCC signatures to predict the sensitivity and specificity of 5-year survival. (H) Time-dependent c-index curve analysis of different HCC signatures. ROC, receiver operating characteristic; HCC, hepatocellular carcinoma.