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. 2022 Jun 6;298(8):102109. doi: 10.1016/j.jbc.2022.102109

Figure 2.

Figure 2

Comparison of the activator domains 1 and 2 (Act1 and Act2).A, crystallographic structure. Gly-Pro-Hyp-bound Act1 (Thr125–Asn223) and Act2 (Gly224–Asp315) are shown in light orange and light blue, respectively, after superposition. Side chains of the residues (Arg167, Tyr175, Glu215, Asp221, Glu308, and Arg311) with hydrogen bond and C-C contact are shown in blue stick. The number indicates the distance (Å) between the atoms. B, structure sequence alignment after superposition by COOT. The RMSD for 152 C-alpha pair is calculated to be 3.3 Å. Red box indicates the residues with hydrogen bond and C–C contact. Yellow box indicates the residues with only C–C contact. The helix region is drawn in gray color.