Table 2.
Blood chemistry and cell death in heart, lung, liver, and kidney after i.v. injection of anti-ceramide antibodies or phosphatidic acid
| Criteria | Untreated | Anti-ceramide-antibody i.v. | Phosphatidic acid i.v. |
|---|---|---|---|
| T-Pro | 5.6 ± 0.2 | 5.0 ± 0.3 | 4.9 ± 0.3 |
| Alb | 2.7 ± 0.05 | 2.5 ± 0.05 | 2.4 ± 0.1a |
| T-Bil | 0.25 ± 0.06 | 0.19 ± 0.03 | 0.23 ± 0.08 |
| GOT | 50.3 ± 16.7 | 39.3 ± 4.8 | 62 ± 36.6 |
| GPT | 20.8 ± 9.4 | 26.5 ± 18.0 | 45.5 ± 22.9 |
| LDH | 629 ± 289 | 493 ± 240 | 560 ± 87 |
| BUN | 26.0 ± 2.7 | 22.3 ± 1.0 | 19 + 15.8 |
| CPK | 958 ± 299 | 741 ± 101 | 766 ± 245 |
| γGT | under 10 IU/L | under 10 IU/L | under 10 IU/L |
| Crea | under 0.2 mg/dL | under 0.2 mg/dL | under 0.2 mg/dL |
| Amylase | 915 ± 189 | 814 ± 113 | 1031 ± 153 |
| Cell death heart | 2 ± 2 | 3 ± 2 | 1 ± 1 |
| Cell death lung | 3 ± 2 | 2 ± 2 | 4 ± 3 |
| Cell death liver | 2 ± 1 | 3 ± 2 | 2 ± 2 |
| Cell death kidney | 3 ± 2 | 4 ± 3 | 3 ± 3 |
Blood plasma was analyzed using a SpotChem EZ chemistry analyzer with the corresponding parameter strips or a colorimetric assay kit. Cell death in the tissues was determined by TUNEL assays and microscopic analysis. Shown are the mean ± SD of each four independent measurements.
Abbreviations: T-Pro, T-Troponin (cardiac Troponin); Alb, albumin, T-Bil, total bilirubin; GOT, glutamat-oxalat transaminase; GPT, glutamat-pyruvat transaminase; LDH, lactatedehydrogenase; BUN, blood urea nitrogen; CPK, creatine-phosphokinase; γGT, gamma-glutamyl-transferase; Crea, Creatinine.
a
p < 0.05, ANOVA and post hoc Tukey test.