FIGURE 1.

Project workflow. An outline of the project workflow from scan acquisition to final statistical analyses. (1) Persistent MDD symptoms lead to (2) the breakdown of the blood brain barrier via inflammatory cytokines such as IL‐1, IL‐6, and TNF‐α; (3) 7T MRI scans along with whit matter mask data were collected on a Siemens 7T whole body scanner; (4) the white matter data were coregistered into the T2‐space using FreeSurfer; (5) semi‐automated PVS markings were generated using a Frangi‐based edge detection filter; (6) statistical analyses were run correlating various trauma scores to PVS quantification measures