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. 2022 Jul 8;13:946711. doi: 10.3389/fmicb.2022.946711

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Copyright © 2022 Schut, Haja, Feng, Poole, Li and Adams.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Phylogenetic tree of Bfu enzymes based on BfuB and distribution of characterized and predicted functions as defined by the third substrate. Left: tree based on 1558 BfuB homologs (containing InterPro domains IPR011538, IPR019554, IPR019575, and IPR017896). BfuB clades were defined as having a branch root length of <0.33 to minimize the number of clades while highlighting functional differences, leading to 57 total clades (23 orphan clades). Clades with predicted functions are numbered. Right: number (#) of different enzymes in each clade classified by the third substrate utilized [in addition to Fd and NAD(H)]. Clade sizes are proportional to the number of members. The non-bifurcating BfuB homolog Nqo1 from Thermus thermophilus was used as the outgroup.