Table 3.
Univariate and multivariate Cox proportional hazards regression analysis of patients with GCLM in the OS group.
| Variables Univariate Cox regression analysis Multivariate Cox regression analysis | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | ||||||
| age | |||||||||||
| <65 | 1 (reference) | 1 (reference) | |||||||||
| >65 | 1.359 | 1.215–1.521 | 0.000 | 1.194 | 1.061–1.343 | 0.003 | |||||
| Sex | |||||||||||
| female | 1 (reference) | ||||||||||
| male | 1.124 | 0.994–1.272 | 0.062 | ||||||||
| Race | |||||||||||
| American Indian/Alaska Native | 1 (reference) | ||||||||||
| Asian/Pacific Islander | 0.572 | 0.301–1.087 | 0.088 | ||||||||
| Black | 0.592 | 0.314–1.118 | 0.106 | ||||||||
| White | 0.605 | 0.324–1.129 | 0.114 | ||||||||
| Grade | |||||||||||
| I | 0.682 | 0.483–0.965 | 0.030 | 0.566 | 0.399–0.805 | 0.002 | |||||
| II | 1(reference) | 1 (reference) | |||||||||
| III | 1.382 | 1.225–1.561 | 0.000 | 1.456 | 1.287–1.648 | 0.000 | |||||
| IV | 0.683 | 0.483–0.965 | 0.331 | 1.416 | 0.906–2.211 | 0.127 | |||||
| T Stage | |||||||||||
| T0 | 1(reference) | 1(reference) | |||||||||
| T1 | 4.165 | 0.585–29.65 | 0.154 | 4.816 | 0.671–34.577 | 0.118 | |||||
| T2 | 2.921 | 0.405–21.06 | 0.288 | 4.142 | 0.569–30.161 | 0.161 | |||||
| T3 | 3.052 | 0.428–21.76 | 0.266 | 4.502 | 0.625–32.459 | 0.135 | |||||
| T4 | 3.960 | 0.556–28.21 | 0.170 | 5.146 | 0.714–37.076 | 0.104 | |||||
| N Stage | |||||||||||
| N0 | 1 (reference) | 1(reference) | |||||||||
| N1 | 0.865 | 0.767–0.977 | 0.019 | 0.910 | 0.802–1.033 | 0.146 | |||||
| N2 | 0.714 | 0.576–0.886 | 0.002 | 0.845 | 0.672–1.063 | 0.151 | |||||
| N3 | 0.836 | 0.674–1.036 | 0.102 | 1.188 | 0.940–1.501 | 0.150 | |||||
| Radiation | |||||||||||
| Yes | 0.919 | 0.796–1.061 | 0.252 | ||||||||
| No | 1 (reference) | ||||||||||
| Chemotherapy | |||||||||||
| Yes | 0.329 | 0.293–0.370 | 0.000 | 0.268 | 0.235–0.305 | 0.000 | |||||
| No | 1 (reference) | 1 (reference) | |||||||||
| Surgery | |||||||||||
| Yes | 0.583 | 0.496–0.685 | 0.000 | 0.476 | 0.394–0.574 | 0.000 | |||||
| No | 1 (reference) | 1 (reference) | |||||||||
| Bone Metastasis | |||||||||||
| Yes | 1.250 | 1.026–1.524 | 0.027 | 1.256 | 1.025–1.540 | 0.028 | |||||
| No | 1 (reference) | 1 (reference) | |||||||||
| Brain Metastasis | |||||||||||
| Yes | 1.368 | 0.808–2.318 | 0.244 | ||||||||
| No | 1 (reference) | ||||||||||
| Lung Metastasis | |||||||||||
| Yes | 1.526 | 1.312–1.775 | 0.000 | 1.511 | 1.293–1.766 | 0.000 | |||||
| No | 1 (reference) | 1 (reference) | |||||||||
| Marital | |||||||||||
| Yes | 0.965 | 0.860–1.082 | 0.540 | ||||||||
| No | 1 (reference) | ||||||||||
| Primary site | |||||||||||
| Cardia | 1.050 | 0.889–1.240 | 0.564 | 1.096 | 0.920–1.306 | 0.304 | |||||
| Pylorus | 0.982 | 0.598–1.614 | 0.943 | 0.886 | 0.537–1.462 | 0.637 | |||||
| Body | 1.141 | 0.904–1.441 | 0.266 | 1.044 | 0.825–1.322 | 0.719 | |||||
| Antrum | 1 (reference) | 1(reference) | |||||||||
| Fundus | 1.240 | 0.930–1.653 | 0.142 | 1.079 | 0.806–1.445 | 0.610 | |||||
| Lesser curve | 1.043 | 0.798–1.363 | 0.00475 | 0.958 | 0.732–1.254 | 0.754 | |||||
| Greater curve | 1.414 | 1.015–1.969 | 0.040 | 1.211 | 0.864–1.696 | 0.267 | |||||
| other | 1.306 | 1.075–1.587 | 0.007 | 1.108 | 0.910–1.350 | 0.308 | |||||
| Histologic type | |||||||||||
| Adenocarcinoma | 1 (reference) | ||||||||||
| Signet ring cell | 1.152 | 0.928–1.429 | 0.200 | ||||||||
| Other | 1.057 | 0.876–1.275 | 0.566 | ||||||||