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. 2022 Jul 8;13:951582. doi: 10.3389/fimmu.2022.951582

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Copyright © 2022 Feng, Xu, Dai, Yin, Zhang and Shen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CAFs spatially associate with Treg cells and survival analysis-based CAFs and stromal score. (A) Immunofluorescence staining of the original ovarian tissue samples. (B) Immunofluorescence staining results of recurrent ovarian tissue samples. (C) The Kaplan–Meier analysis of GPL570 meta-cohort, including CAF_EPIC (i), Fibroblasts_MCPcounter (ii), Fibroblasts_xCell (iii), and StromalScore_estimate (iv). (D) The Kaplan–Meier analysis of TCGA-OV cohort, including CAF_EPIC (i), Fibroblasts_MCPcounter (ii), Fibroblasts_xCell (iii), and StromalScore_estimate (iv). CAFs, Cancer-Associated Fibroblasts; Tregs, Regulatory T cells.