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Functional analyses and construction of the CAF-based signature. (A) (i) Differentially mutated genes in different risk groups. (ii) CAF marker mutations in different risk groups. (B) TMB values in different risk groups. (C) Spearman analysis between CAF risk score and TMB values. (D) Correlation analysis between TMB values, stromal/CAF scores, and CAF-activating factors. CAFs, Cancer-Associated Fibroblasts; TMB, Tumor Mutational Burden.
