Table 4.
Key auxological measurements for patients with congenital CPHD.
| Group Ia | Group IIb | p-value (effect size) | |
|---|---|---|---|
| Number of patientsc | 12 | 11 | ·· |
| Birth data | ·· | ·· | ·· |
| data availability: n | 12 | 11 | ·· |
| Birth length (SDS): mean (SD) | -0·4 (1·2) | 0·2 (0·9) | p=0·117 (d=-0·513)d |
| Birth weight for height (%): mean (SD) | 5 (11) | 0 (8) | p=0·113 (d=0·521)d |
| Target height (TH) | ·· | ·· | ·· |
| data availability: n | 10 | 10 | ·· |
| TH SDS: median (IQR) | -0·2 (-0·4 to 1·1) | -0·3 (-0·5 to 0·2) | p=0·353 (r=0·221)e |
| TH SDS: range | -0·6 to 1·4 | -0·7 to 0·4 | ·· |
| First violation of the growth screening rules | ·· | ·· | ·· |
| data availability: n | 8 | 11 | ·· |
| HSDS: median (IQR) | -3·1 (-3·9 to -1·5) | -2·5 (-2·8 to -1·8) | p=0·272 (r=0·266)e |
| HSDS: range | -4·7 to -1·1 | -3·0 to -1·3 | ·· |
| Age (years): median (IQR) | 0·3 (0·3 to 0·5) | 1·8 (1·3 to 2·0) | p<0·0001 (r=0·845)e |
| Age (years): range | 0·3 to 0·5 | 0·8 to 4·0 | ·· |
| Delay to GH treatment | ·· | ·· | ·· |
| data availability: n | 8 | 11 | ·· |
| years: median (IQR) | 1·9 (0·6 to 6·1) | 2·5 (1·2 to 3·2) | p=0·778 (r=-0·076)e |
| years: range | 0·0 to 11·0 | 0·6 to 7·0 | ·· |
| Latest height measurement | ·· | ·· | ·· |
| data availability: n | 11 | 11 | ·· |
| HSDS: median (IQR) | -0·6 (-2·1 to 0·1) | -0·6 (-1·6 to 0·0) | p=0·797 (r=0·063)e |
| HSDS: range | -4·8 to 0·8 | -2·7 to 0·8 | ·· |
| Age (years): median (IQR) | 16·7 (8·5 to 17·7) | 15·2 (13·6 to 18·2) | p=0·847 (r=0·042)e |
| Age (years): range | 2·9 to 19·0 | 9·9 to 19·7 | ·· |
a
Group I, patients with HSDS deviation during the first six months of life; four patients with the start of GH Rx treatment prior to the age of 0·25 years included only in the birth and final height measures.
b
Group II, patients with HSDS deviation between six months to four years of age.
c
Data available for 26 patients. Two patients who had not been diagnosed with GHD and one with growth deviation first at the age of 12 years are not shown.
d
T-test and Cohen's d.
e
Mann-Whitney U-test and r.
CPHD, combined pituitary hormone deficiency; HSDS, height SDS; GHD, growth hormone deficiency.