Figure 1.

Graphical representation of hierarchical analysis of global ASV distribution at L6 (genus) for COVID-19 and CTRL subjects filtered by a t-test between classes with p-value < 0.05 at T₀. In the heatmap, the hierarchical complete linkage dendrogram is based on the ASVs Pearson’s correlation coefficient. The color scale characterizes the Z-score for each variable: red, high level; blue, low level. The column color labels represent respectively: patient’s class (red, COVID-19; orange, Non–COVID-19; green, CTRLs), gender (blue, male; pink, female), severity (green, asymptomatic; orange, mild; red, moderate), and antibiotic [green, absent (0); red, present (1)].