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. 2022 Jul 8;13:874863. doi: 10.3389/fimmu.2022.874863

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Copyright © 2022 Zhang, Salgado, Liu, Moazzami, Hogquist, Farrar and Ruan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Protection of Foxp3^YFP-Cre/YRosa26^Stat5b-CA/wt mice from diet-induced obesity. (A) Body weight of Foxp3^YFP-Cre/Y (n = 9) and Foxp3^YFP-Cre/YRosa26^Stat5b-CA/wt (n = 6) mice after HFD feeding. (B) Lean and fat mass of HFD-fed Foxp3^YFP-Cre/Y (n = 9) and Foxp3^YFP-Cre/YRosa26^Stat5b-CA/wt (n = 6) mice. (C) Weight of BAT, gonadal WAT, and liver of HFD-fed Foxp3^YFP-Cre/Y (n = 5) and Foxp3^YFP-Cre/YRosa26^Stat5b-CA/wt (n = 5) mice. (D) Cumulative food intake of Foxp3^YFP-Cre/Y (n = 7) and Foxp3^YFP-Cre/YRosa26^Stat5b-CA/wt (n = 4) mice when switched to HFD feeding. (E) Body weight-adjusted heat production and (F) locomotor activity of HFD-fed Foxp3^YFP-Cre/Y (n = 11) and Foxp3^YFP-Cre/YRosa26^Stat5b-CA/wt (n = 6) mice, determined by metabolic cages. (G) Fecal energy and (H) fecal lipid percentage of HFD-fed Foxp3^YFP-Cre/Y (n = 8) and Foxp3^YFP-Cre/YRosa26^Stat5b-CA/wt (n = 6) mice. (I) Glucose tolerance test of HFD-fed Foxp3^YFP-Cre/Y (n = 9) and Foxp3^YFP-Cre/YRosa26^Stat5b-CA/wt (n = 6) mice. Area under curve (AUC) is shown to the right. Data are presented as mean ± SEM. n.s., not significant; *, p < 0.05; **, p < 0.01; ***, p < 0.001 by unpaired student’s t-test or two-way ANOVA (A, I).