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. 2022 May 13;14(2):494–511. doi: 10.1016/j.jcmgh.2022.05.002

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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IE2-specific expression altered the expression level of genes in the liver. (A) Heatmap representing the correlation coefficient of samples between Rosa26-LSL-IE2^+/- mice, wild-type mice, and Rosa26-LSL-IE2^+/-, cre mice. The closer the correlation coefficient (R2) is to 1, the higher the similarity of expression patterns between samples. (B) Principal component analysis (PCA) was used to evaluate the differences between 3 groups and the repeatability of samples within groups. (C) Comparing the distribution of exon, intron, and intergenic regions of the genome to detect the source of sequence in the genome. (D) The gene number of up-regulation and down-regulation in the Rosa26-LSL-IE2^+/-, cre group compared with the Rosa26-LSL-IE2^+/-group. (E) Heatmap representing alteration of hepatic gene expression. Blue represents a down-regulation in expression and red represents up-regulation when compared with Rosa26-LSL-IE2^+/-. (F) Validation of top DEGs by quantitative real-time PCR. Top DEGs were up-regulated (up) and down-regulated (down). Error bars represent SEM. The Student t test was used to analyze statistical differences. ∗∗∗P < .001. n = 3 mice per group.