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. 2022 May 13;14(2):494–511. doi: 10.1016/j.jcmgh.2022.05.002

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Construction of Rosa26-LSL-IE2^+/-, cre mice. First, Rosa26-LSL-IE2^+/- model mice were constructed. Next, Rosa26-LSL-IE2^+/-, cre mice were obtained by Rosa26-LSL-IE2^+/- mice mating with albumin-Cre mice. IE2^+/- represents Rosa26-LSL-IE2^+/-; Cre^+/- represents Rosa26-LSL-IE2^+/-, cre. Amp, ampicillin resistance screening gene; CAG, CAG_promoter; loxp, locus of X-overP1; SacII represents SacII Restriction Endonuclease; STOP_represents transcription termination element; WPRE, Woodchuck hepatitis virus post-transcriptional regulatory element; -/-, wild-type, IE2^+/-.