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. 2022 May 13;14(2):435–464. doi: 10.1016/j.jcmgh.2022.05.003

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

SZN-1326-p increased barrier gene expression and led to barrier marker restoration in the DSS injury model. (A) Differential gene expression values for significantly enriched mucin and barrier associated genes in the indicated epithelial cell type, comparing DSS/SZN-1326-p with DSS/anti-GFP. (B) Immunofluorescence staining of the tight junction marker TJP1 (ZO-1) (green) in transverse colon samples of the indicated treatment at day 10. Nuclei were counterstained with DAPI (blue). Scale bar = 100 μm.