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. 2022 May 13;14(2):435–464. doi: 10.1016/j.jcmgh.2022.05.003

Figure 2.

Figure 2

Wnt mimetics alone did not cause hyperproliferation in the damaged colon or in the small intestine. (A–H) Ki67 staining of duodenum sections of animals treated with (A) no DSS, (B) DSS with PBS injections, (C) DSS with 2 IP injections of 3 mg/kg anti-GFP, (D) DSS with 2 IP injections of 10 mg/kg R2M3-26, (E) DSS with 2 IP injections of 3 mg/kg RSPO2, (F) DSS with daily IP injections of 3 mg/kg RSPO2, (G) DSS with 2 IP injections of 1 mg/kg RSPO2 + 0.3 mg/kg R2M3-26 combo, and (H) DSS with daily IP injections of 1 mg/kg RSPO2 + 0.3 mg/kg R2M3-26 combo. (I–P) Ki67 staining of transverse colon sections of animals treated with Ki67 staining of duodenum sections of animals treated with (I) no DSS, (J) DSS with PBS injections, (K) DSS with 2 IP injections of 3 mg/kg anti-GFP, (L) DSS with 2 IP injections of 10 mg/kg R2M3-26, (M) DSS with 2 IP injections of 3 mg/kg RSPO2, (N) DSS with daily IP injections of 3 mg/kg RSPO2, (O) DSS with 2 IP injections of 1 mg/kg RSPO2 + 0.3 mg/kg R2M3-26 combo, and (P) DSS with daily IP injections of 1 mg/kg RSPO2 + 0.3 mg/kg R2M3-26 combo. Scale bars = 100 μm.