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The FZD family of receptors showed differential expression pattern in the small intestinal epithelium. (A–L) expression of each of the 10 Fzd receptors Fzd1–10, Axin2 and Lgr5 in the normal duodenum was examined by RNAscope in situ hybridization. (A’–L’) insets with zoom in view showing Fzd expression in the small intestinal crypts. Arrows in E’ indicate intestinal stem cells. Scale bars = 100 μm.
