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. 2022 May 13;14(2):435–464. doi: 10.1016/j.jcmgh.2022.05.003

Figure 5.

Figure 5

The Fzd5,8-specific Wnt mimetic, SZN-1326-p, effectively promoted intestinal organoid growth. (A–T) Representative mouse small intestinal organoids treated with a dose titration of the indicated Wnt mimetic with different Fzd specificity. For each protein, organoids were treated with, from left to right, (A, F, K, P) 10 pM, (B, G, L, Q) 100 pM, (C, H, M, R) 1 nM, (D, I, N, S) 10 nM, or (E, J, O, T) 100 nM of the negative control anti-βGal or the indicated Wnt mimetic in the presence of 10 nM IWP2 in basal media. (U) Organoids grew in basal media. (V) Organoids treated with only 10 nM IWP2 in basal media. Scale bars = 100 μm.