Table 3.
Characteristics of patients admitted in ICU with aPL positivity.
| Characteristics | Non-COVID-19 patients with aPL positivity (n = 9) | COVID-19 patients with aPL positivity (n = 20) | p |
|---|---|---|---|
| Age (mean ± SD) | 55.9 ± 14.0 | 64.1 ± 7.9 | 0.13 |
| Male gender (n, %) | 5 (55.6) | 15 (75.0) | 0.30 |
| aPL positivity (n, %) | |||
| aCL IgG | 8 (88.9) | 17 (85) | 0.78 |
| aCL IgM | 1 (11.1) | 5 (25) | 0.39 |
| aB2GP1 IgG | 0 | 1 (5) | 0.49 |
| aB2GP1 IgM | 1 (11.1) | 2 (10) | 0.93 |
| Level of aPL (U/mL) | |||
| aCL IgG | 30.3 ± 17.2 | 28.6 ± 16.5 | 0.81 |
| aCL IgM | 10.7 ± 12.1 | 9.1 ± 6.3 | 0.72 |
| aB2GP1 IgG | 1.8 ± 0.8 | 2.3 ± 2.8 | 0.45 |
| aB2GP1 IgM | 2.7 ± 3.3 | 5.2 ± 12.6 | 0.42 |
| Comorbidities | |||
| Autoimmune disease | 4 (44.4) | 1 (5) | 0.02 |
| Cardiovascular disease | 1 (11.1) | 4 (20) | 1 |
| Hypertension | 2 (22.2) | 6 (30) | 1 |
| Diabetes | 2 (22.2) | 6(30) | 1 |
| Dyslipidemia | 0 | 6 (30) | 0.14 |
| Evolution in ICU | |||
| ARDS | 2 (22.2) | 20 (100) | < 0.0001 |
aPL antiphospholipid, aCL anti-cardiolipin, aB2GPI anti-beta-2 glycoprotein I autoantibodies, ICU intensive care unit, ARDS acute respiratory distress syndrome, n number.