Table 1.
Comparison of wound healing, cancer and COVID-19
| Parameter | Wound healing | Rheumatoid arthritis | Cancer | COVID-19 |
|---|---|---|---|---|
| Recruitment of immune cells | Yes | Yes | Yes | Yes |
| Effect of immune cells on non-immune cell proliferation | Yes (fibroblasts + re-epithelization) | Yes (fibroblasts) | Yes (cancer cells + their migration) | Yes (fibroblasts) |
| Cytokine storm | Almost not | Yes (rare) | Yes (cancer cachexia) | Yes |
| IL-6 elevation | Yes | Yes | Yes | Yes |
| Stromal reaction | Yes (granulation tissue) | Yes (pannus) | Yes (cancer stroma) | Yes (inter-alveolar septa) |
| ECM production | Yes | Yes | Yes | Yes |
| Myofibroblasts | Yes | Yes | Yes | Yes |
| Final effect | Wound closure | Progression of articular/extra-articular signs | Growth + metastasizing | Disease progression + fatal termination |