Figure 1.

Genome-wide association with functional assay-positive status in the discovery cohort. P values were generated using logistic regression adjusted for age, sex, and principal components 1-3 in an additive model. P values on the −log₁₀ scale are plotted on the left vertical axis, and the chromosomal position is plotted along the horizontal axis. The significance threshold of 5 × 10⁻⁸ is indicated by the solid red horizontal line, and the suggestive threshold of 1 × 10⁻⁶ is indicated by the red dashed horizontal line. ORs are indicated by dot color as described in the legend on the right.