Table 2.

AEs through week 112 of the DISCOVER‐2 study^*

	Placebo (weeks 0–24) (n = 246)	Placebo–guselkumab Q4W crossover(weeks 24–112)(n = 238)	Guselkumab Q4W (weeks 0–112) (n = 245)	Guselkumab Q8W (weeks 0–112) (n = 248)	All guselkumab (n = 731)†
Duration of follow‐up, weeks	24.4	84.2	106.4	107.1	99.4
Patient‐years of follow‐up	115	384	499	509	1,392
AEs
No. patient‐years	85	240	225	224	690
Patients	101 (41)	126 (53)	172 (70)	178 (72)	476 (65)
No. events per 100 patient‐  years (95% CI)	188.9 (164.6, 215.8)	110.7 (100.5, 121.8)	121.2 (111.7, 131.2)	158.0 (147.3, 169.3)	131.7 (125.8, 137.9)
Serious AEs
No. patient‐years	113	368	476	487	1,330
Patients	7 (3)	16 (7)	22 (9)	22 (9)	60 (8)
No. events per 100 patient‐   years (95% CI)	6.1 (2.5, 12.6)	6.0 (3.8, 9.0)	5.2 (3.4, 7.6)	6.1 (4.1, 8.7)	5.8 (4.6, 7.2)
AEs leading to study discontinuation
No. patient‐years	114	381	496	507	1,383
Patients	4 (2)	10 (4)	13 (5)	8 (3)	31 (4)
No. events per 100 patient‐    years (95% CI)	3.5 (1.0, 8.9)	2.9 (1.4, 5.1)	3.2 (1.8, 5.2)	1.6 (0.7, 3.1)	2.5 (1.8, 3.5)
Infections
No. patient‐years	104	315	378	381	1,075
Patients	45 (18)	61 (26)	82 (34)	94 (38)	237 (32)
No. events per 100 patient years (95% CI)	50.5 (38.3, 65.3)	34.9 (29.3, 41.4)	35.8 (30.8, 41.5)	40.5 (35.1, 46.4)	37.3 (34.1, 40.6)
Serious infections
No. patient‐years	115	378	496	504	1,378
Patients	1 (0.4)	8 (3)	5 (2)	8 (3)	21 (3)
No. events per 100 patient‐ years (95% CI)	0.9 (0.02, 4.9)	2.6 (1.3, 4.8)	1.0 (0.3, 2.3)	2.2 (1.1, 3.9)	1.9 (1.2, 2.7)

^*Except where indicated otherwise, values are the number (%) of patients. AEs = adverse events; 95% CI = 95% confidence interval; Q4W = every 4 weeks; Q8W = every 8 weeks.

^†Includes all patients who received ≥1 administration of guselkumab, including patients who crossed over from placebo at week 24.