Table 1.
Inhibition values by 5‐substituted 2‐pyrrol‐1‐benzoic acid derivatives (1–8) determined using the coupled photometric assay with purified PfIspD.
|
| ||
|---|---|---|
|
Compd |
R |
IC50 [μm]* |
|
1 |
NO2 |
271±24 |
|
2 |
H |
>500 |
|
3 |
Cl |
263±35 |
|
4 |
Br |
117±20 |
|
5 |
I |
208±37 |
|
6 |
CH3 |
>500 |
|
7 |
−OCH3 |
>500 |
|
8 |
−NHCOCH3 |
>500 |